Anti‐inflammatory evaluation of cryogenine
Identifieur interne : 003D10 ( Main/Exploration ); précédent : 003D09; suivant : 003D11Anti‐inflammatory evaluation of cryogenine
Auteurs : Harvey R. Kaplan [États-Unis] ; Richard E. Wolke [États-Unis] ; Marvin H. Malone [États-Unis]Source :
- Journal of Pharmaceutical Sciences [ 0022-3549 ] ; 1967-11.
English descriptors
- Teeft :
- Abdominal skin, Adjuvant, Analgesia, Analgesic, Analgesic activity, Antagonism studies, Antiphlogistic evaluation, Antipyretic, Antipyretic evaluation, Aqueous solution, Aspirin, Body weight, Bone proliferation, Bradykinin, Caliper technique, Carrageenin, Carrageenin injection, Cent analgesia, Chloroquine, Cinnamic acid, Clot lysis, Consultants bureau, Contralateral foot, Control animal, Control animals, Creatinine sulfate, Cryogenine, Cryogenine base, Cryogeninetreated rats, Daily administration, Detectable lysis, Drug administration, Edema, Electric timer, Experimental procedures, Femorotibial articulations, Foot thickness, Histamine, Histamine diphosphate, Histopathological studies, Indomethacin, Inflammatory response, Inflammatory responses, Injection, Joint cavity, Keinhold publishing corp, Lesion, Local suppliers, Medial foot thickness, Metatarsal areas, Mononuclear cells, Multiple range test, Mycobacterium adjuvant, Narcotic analgesics, Oral dosage, Pain responses, Pharmaceutical sciences, Phenylbutazone, Plantar aponeurosis, Plantar injection, Preformed clots, Present address, Rat, Reaction time, Reaction times, Rectal temperatures, Reference agents, Sediment formation, Serotonin, Significant analgesia, Significant difference, Significant protection, Silver nitrate, Sparteine, Standard errors, Synovial membrane, Synthetic bradykinin, Tail flick, Test drugs, Test group, Thickness right feet, Transverse sections, Treatment effects, Treatment groups, Untreated controls.
Abstract
Cryogenine was effective in limiting the development of artificially induced inflammatory responses in acute and chronic experiments in rats. Cryogenine altered the acute edematous reaction to plantar injection of carrageenin and inhibited development of increased foot thickness induced by plantar injection of nonviable mycobacterial adjuvant in chronic studies. Histopathologic examinations did not suggest actions that would interfere with the anti‐inflammatory evaluations. Cryogenine demonstrated a low order of analgesic (rat tail flick) and antipyretic (peptone fever) activity, and was capable of partially reversing edema and pain produced by silver nitrate injections in the ankle joints of rats. Cryogenine blocked serotonin, bradykinin, and histamine responses in guinea pig ileum; and pretreatment limited serotonin‐induced pedal edema in rats and blocked histamine‐induced intradermal wheals in the rabbit. Cryogenine was ineffective as a fibrinolytic agent. Prototype nonsteroidal anti‐inflammatory compounds as well as agents with structural similarities to cryogenine were also investigated. Cryogenine may, like aspirin, manifest its anti‐inflammatory activity through a combination of selective central and nonspecific peripheral mechanisms.
Url:
DOI: 10.1002/jps.2600561103
Affiliations:
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Cryogenine altered the acute edematous reaction to plantar injection of carrageenin and inhibited development of increased foot thickness induced by plantar injection of nonviable mycobacterial adjuvant in chronic studies. Histopathologic examinations did not suggest actions that would interfere with the anti‐inflammatory evaluations. Cryogenine demonstrated a low order of analgesic (rat tail flick) and antipyretic (peptone fever) activity, and was capable of partially reversing edema and pain produced by silver nitrate injections in the ankle joints of rats. Cryogenine blocked serotonin, bradykinin, and histamine responses in guinea pig ileum; and pretreatment limited serotonin‐induced pedal edema in rats and blocked histamine‐induced intradermal wheals in the rabbit. Cryogenine was ineffective as a fibrinolytic agent. Prototype nonsteroidal anti‐inflammatory compounds as well as agents with structural similarities to cryogenine were also investigated. Cryogenine may, like aspirin, manifest its anti‐inflammatory activity through a combination of selective central and nonspecific peripheral mechanisms.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Connecticut</li><li>New Jersey</li></region></list><tree><country name="États-Unis"><region name="Connecticut"><name sortKey="Kaplan, Harvey R" sort="Kaplan, Harvey R" uniqKey="Kaplan H" first="Harvey R." last="Kaplan">Harvey R. Kaplan</name></region><name sortKey="Kaplan, Harvey R" sort="Kaplan, Harvey R" uniqKey="Kaplan H" first="Harvey R." last="Kaplan">Harvey R. Kaplan</name><name sortKey="Malone, Marvin H" sort="Malone, Marvin H" uniqKey="Malone M" first="Marvin H." last="Malone">Marvin H. Malone</name><name sortKey="Wolke, Richard E" sort="Wolke, Richard E" uniqKey="Wolke R" first="Richard E." last="Wolke">Richard E. Wolke</name><name sortKey="Wolke, Richard E" sort="Wolke, Richard E" uniqKey="Wolke R" first="Richard E." last="Wolke">Richard E. Wolke</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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